%PDF-1.4
%
1 0 obj
<<
/Type /Catalog
/Version /1.4
/Pages 2 0 R
/PageLabels 3 0 R
/Metadata 4 0 R
/Names 5 0 R
/Outlines 6 0 R
>>
endobj
7 0 obj
<<
/Author (Na Chen)
/CreationDate (D:20220610164826+05'30')
/Creator (Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64)
/Keywords (IAV; SARS-CoV-2; virus-host interactions; replication cycle; host innate immunity; antiviral drug targets; Omicron)
/ModDate (D:20221206183746+05'30')
/Producer (Acrobat Distiller 8.1.0 \(Windows\))
/Subject (Emerging Microbes & Infections, 2022. doi:10.1080/22221751.2022.2071175)
/Title (Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2)
>>
endobj
2 0 obj
<<
/Type /Pages
/Kids [8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R
18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R]
/Count 20
>>
endobj
3 0 obj
<<
/Nums [0 28 0 R 1 29 0 R]
>>
endobj
4 0 obj
<<
/Length 4349
/Subtype /XML
/Type /Metadata
>>
stream
Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64
2022-12-06T18:37:46+05:30
2022-06-10T16:48:26+05:30
2022-12-06T18:37:46+05:30
application/pdf
10.1080/22221751.2022.2071175
en
Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2
Na Chen
Emerging Microbes & Infections, 2022. doi:10.1080/22221751.2022.2071175
IAV
SARS-CoV-2
virus-host interactions
replication cycle
host innate immunity
antiviral drug targets
Omicron
Acrobat Distiller 8.1.0 (Windows)
IAV; SARS-CoV-2; virus-host interactions; replication cycle; host innate immunity; antiviral drug targets; Omicron
uuid:d101e102-4f57-402c-b5f5-e5e27f46d341
uuid:f03feb51-029e-463e-ab5b-f39edc145d55
Journal
Emerging Microbes & Infections
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
11
1
1371
1389
10.1080/22221751.2022.2071175
https://doi.org/10.1080/22221751.2022.2071175
VoR
10.1080/22221751.2022.2071175
2022-05-23
True
www.tandfonline.com
10.1080/22221751.2022.2071175
2022-05-23
True
www.tandfonline.com
endstream
endobj
5 0 obj
<<
/Dests 30 0 R
/EmbeddedFiles 31 0 R
>>
endobj
6 0 obj
<<
/Count 17
/First 32 0 R
/Last 33 0 R
/Type /Outlines
>>
endobj
8 0 obj
<<
/Resources 34 0 R
/Type /Page
/MediaBox [0.0 0.0 634.32 833.04]
/CropBox [0.0 0.0 634.32 833.04]
/BleedBox [0 0 634.32 833.04]
/TrimBox [0 0 634.32 833.04]
/Parent 2 0 R
/Annots [35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R
45 0 R 46 0 R]
/Contents 47 0 R
/Rotate 0
>>
endobj
9 0 obj
<<
/Annots [48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R
58 0 R 59 0 R 60 0 R 61 0 R 62 0 R]
/Contents [63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R]
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 71 0 R
/Rotate 0
/Thumb 72 0 R
/Type /Page
>>
endobj
10 0 obj
<<
/Annots [73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R
83 0 R 84 0 R 85 0 R]
/Contents 86 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 87 0 R
/Rotate 0
/Thumb 88 0 R
/Type /Page
>>
endobj
11 0 obj
<<
/Annots [89 0 R 90 0 R 91 0 R]
/Contents 92 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 93 0 R
/Rotate 0
/Thumb 94 0 R
/Type /Page
>>
endobj
12 0 obj
<<
/Annots [95 0 R]
/Contents 96 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 97 0 R
/Rotate 0
/Thumb 98 0 R
/Type /Page
>>
endobj
13 0 obj
<<
/Annots [99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R
109 0 R 110 0 R 111 0 R 112 0 R 113 0 R]
/Contents 114 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 115 0 R
/Rotate 0
/Thumb 116 0 R
/Type /Page
>>
endobj
14 0 obj
<<
/Annots [117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R
127 0 R 128 0 R 129 0 R]
/Contents 130 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 131 0 R
/Rotate 0
/Thumb 132 0 R
/Type /Page
>>
endobj
15 0 obj
<<
/Annots [133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R]
/Contents 139 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 140 0 R
/Rotate 0
/Thumb 141 0 R
/Type /Page
>>
endobj
16 0 obj
<<
/Annots [142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R
152 0 R 153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R
162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R]
/Contents 169 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 170 0 R
/Rotate 0
/Thumb 171 0 R
/Type /Page
>>
endobj
17 0 obj
<<
/Annots [172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R]
/Contents 178 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 179 0 R
/Rotate 0
/Thumb 180 0 R
/Type /Page
>>
endobj
18 0 obj
<<
/Annots [181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R
191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R]
/Contents 200 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 201 0 R
/Rotate 0
/Thumb 202 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/Annots [203 0 R 204 0 R 205 0 R 206 0 R 207 0 R]
/Contents 208 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 209 0 R
/Rotate 0
/Thumb 210 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/Annots [211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R]
/Contents 221 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 222 0 R
/Rotate 0
/Thumb 223 0 R
/Type /Page
>>
endobj
21 0 obj
<<
/Annots [224 0 R 225 0 R 226 0 R 227 0 R 228 0 R]
/Contents 229 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 230 0 R
/Rotate 0
/Thumb 231 0 R
/Type /Page
>>
endobj
22 0 obj
<<
/Annots [232 0 R 233 0 R 234 0 R 235 0 R]
/Contents 236 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 237 0 R
/Rotate 0
/Thumb 238 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/Annots [239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R]
/Contents 248 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 249 0 R
/Rotate 0
/Thumb 250 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/Annots [251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R
261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R 270 0 R
271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R 277 0 R 278 0 R 279 0 R 280 0 R
281 0 R 282 0 R 283 0 R 284 0 R]
/Contents 285 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 286 0 R
/Rotate 0
/Thumb 287 0 R
/Type /Page
>>
endobj
25 0 obj
<<
/Annots [288 0 R 289 0 R 290 0 R 291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R
298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R
308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R
318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R]
/Contents 327 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 328 0 R
/Rotate 0
/Thumb 329 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/Annots [330 0 R 331 0 R]
/Contents 332 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 333 0 R
/Rotate 0
/Thumb 334 0 R
/Type /Page
>>
endobj
27 0 obj
<<
/Contents 335 0 R
/CropBox [0.0 0.0 595.276 841.89]
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/Resources 336 0 R
/Rotate 0
/Thumb 337 0 R
/Type /Page
>>
endobj
28 0 obj
<<
/P (1)
>>
endobj
29 0 obj
<<
/S /D
>>
endobj
30 0 obj
<<
/Kids [338 0 R 339 0 R 340 0 R 341 0 R]
>>
endobj
31 0 obj
<<
/Kids [342 0 R]
>>
endobj
32 0 obj
<<
/Dest
/Next 343 0 R
/Parent 6 0 R
/Title
>>
endobj
33 0 obj
<<
/Dest
/Parent 6 0 R
/Prev 344 0 R
/Title
>>
endobj
34 0 obj
<<
/Font 345 0 R
/ProcSet [/PDF /ImageB /ImageC /Text]
/XObject <<
/Im3 346 0 R
/Im17 347 0 R
/Im11 348 0 R
/Im14 349 0 R
/Im12 350 0 R
/Im10 351 0 R
/Im18 352 0 R
/Im7 353 0 R
/Im5 354 0 R
/Im8 355 0 R
/Im16 356 0 R
/Im4 357 0 R
/Im9 358 0 R
/Im13 359 0 R
/Im2 360 0 R
/Im1 361 0 R
/Im6 362 0 R
/Im15 363 0 R
>>
/ColorSpace 364 0 R
>>
endobj
35 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [155.223 42.905 479.097 51.896]
/C [0 0 0]
/Border [0 0 0]
/A 365 0 R
/H /I
>>
endobj
36 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [283.176 688.444 439.104 696.436]
/C [0 0 0]
/Border [0 0 0]
/A 366 0 R
/H /I
>>
endobj
37 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [259.53 522.145 413.93 532.135]
/C [0 0 0]
/Border [0 0 0]
/A 367 0 R
/H /I
>>
endobj
38 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [202.3 502.145 427.29 512.135]
/C [0 0 0]
/Border [0 0 0]
/A 368 0 R
/H /I
>>
endobj
39 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [106.6 360.905 124.18 369.896]
/C [0 0 0]
/Border [0 0 0]
/A 369 0 R
/H /I
>>
endobj
40 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [131.8 360.391 286.982 369.382]
/C [0 0 0]
/Border [0 0 0]
/A 369 0 R
/H /I
>>
endobj
41 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [106.6 270.647 122.36 279.638]
/C [0 0 0]
/Border [0 0 0]
/A 370 0 R
/H /I
>>
endobj
42 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [131.8 274.591 230.84 283.582]
/C [0 0 0]
/Border [0 0 0]
/A 370 0 R
/H /I
>>
endobj
43 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [106.6 225.127 125.16 234.118]
/C [0 0 0]
/Border [0 0 0]
/A 371 0 R
/H /I
>>
endobj
44 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [131.8 231.691 232.586 240.682]
/C [0 0 0]
/Border [0 0 0]
/A 371 0 R
/H /I
>>
endobj
45 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [106.6 185.476 124.2 194.467]
/C [0 0 0]
/Border [0 0 0]
/A 372 0 R
/H /I
>>
endobj
46 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [131.8 188.791 292.094 197.782]
/C [0 0 0]
/Border [0 0 0]
/A 372 0 R
/H /I
>>
endobj
47 0 obj
<<
/Length 1896
/Filter /FlateDecode
>>
stream
xYn7ST`{w@ANm饯_"%͏7[0h$ɏO'Xn{c'iv&,9$]~=?^]c]~wX>ZmY?.o_u/h{zIubZ}um;kkwq mXeꗆ<ɷy-yh,wwӲk
@%ݲ"KS9^`i|lgT%^
k*S6Gl;sΦ 9u Df3}-+۲ԭ|g3ڒ^OogRN.5Հ8>:ŻߖO9Di\|ߜÑ?/uYHmS2:H۹u Kzm)5MgEÈȡ=ekLNYጋrQtgѥW80Y>7SW@uIXYrX-(l0#{hYmr z)&ͰL>.ցhNREE1,O8Gr\M9#!01eyɨq=D:
y|4OA`챀Dm|uhf2
TCPJMtSjc$
-8,)IW< NupfcٛɊ)=NW#wM'V྇{Yk J<{ .2Sӽysa8{:H}U*n2Pa/$&YvzVP)50d}IPY
YyAdl%Dlw81?V%ӝF:9$4=
ۍ*.c*ZشkZ҄ZDN;Tk'ٗU=Ql | (/{*%B{"bmKC٭ά̝;xvUSs+5ft#}ӈN>i~oENpFvBXaJ';SLB(
c:[H ˡ{/MKxM;W 'aj)_,'FkYqWV!CI2E8䞦ȗ5A|ϒM:y1]F61NPڣL`*#XCpUsUTZ=ݦ$NP݀[J3Ǹ>i7{E, ~۪ KVE%rE
;]:)E]m~EÞn OunE4&.vW2^Q}CdF~(;ZX]U=[:!}a0h_;\T1ܳسOJ0&>w0Kʑj7&:T1RSSp G99:Dc7oraJA4oaiyVVɀl_ D|ӻ\
͈~ju-q8yvrLĬ;J8Dr
n!jrN3 j$co-zU?z3#ldrJ^[rK,\
1J53%)_ĩY93=/NOO;*8%4Bg6C^=}R ăOGB'ϘfDF0SWt
endstream
endobj
48 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [98.135 694.375 101.934 704.92]
/Subtype /Link
/Type /Annot
>>
endobj
49 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [167.414 694.375 171.893 704.92]
/Subtype /Link
/Type /Annot
>>
endobj
50 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [224.334 694.375 228.132 704.92]
/Subtype /Link
/Type /Annot
>>
endobj
51 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [281.65 694.375 285.449 704.92]
/Subtype /Link
/Type /Annot
>>
endobj
52 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [365.556 694.375 369.354 704.92]
/Subtype /Link
/Type /Annot
>>
endobj
53 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [198.255 113.839 203.301 124.328]
/Subtype /Link
/Type /Annot
>>
endobj
54 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [429.052 295.824 434.098 306.312]
/Subtype /Link
/Type /Annot
>>
endobj
55 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [426.671 256.819 431.716 267.307]
/Subtype /Link
/Type /Annot
>>
endobj
56 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [310.28 152.787 315.326 163.276]
/Subtype /Link
/Type /Annot
>>
endobj
57 0 obj
<<
/A 373 0 R
/Border [0 0 0]
/Rect [475.257 751.805 535.294 763.653]
/Subtype /Link
/Type /Annot
>>
endobj
58 0 obj
<<
/A 374 0 R
/Border [0 0 0]
/Rect [355.975 692.334 364.252 700.894]
/Subtype /Link
/Type /Annot
>>
endobj
59 0 obj
<<
/A 375 0 R
/Border [0 0 0]
/Rect [348.831 54.312 469.757 61.342]
/Subtype /Link
/Type /Annot
>>
endobj
60 0 obj
<<
/A 376 0 R
/Border [0 0 0]
/Rect [139.238 90.822 209.82 98.816]
/Subtype /Link
/Type /Annot
>>
endobj
61 0 obj
<<
/A 377 0 R
/Border [0 0 0]
/Rect [376.101 775.559 447.023 797.783]
/Subtype /Link
/Type /Annot
>>
endobj
62 0 obj
<<
/A 378 0 R
/Border [0 0 0]
/Rect [458.986 775.842 535.294 793.871]
/Subtype /Link
/Type /Annot
>>
endobj
63 0 obj
<<
/Length 1746
/Filter /FlateDecode
>>
stream
HWˮ5W]~ob"
,F sN(AW]vrexpz𗏧,i
)-UJ[|Yxsz˭Rlꜷ$AŧzZdɡߕ;Q>>crWQ!#P2W'C>dدNtȰ_a:!~u2H@cدNȰ_a:b;b8Xa:n_B־y뗟ߜ^mi
Y;?H;%G+s?*q'kS68>Wg=+?6gJ{|{uNmm*aO_^㯧_|sy[xT5F'U6O|YV`0:mpsUTe^N\-x?LjH!mrz\38JFZqie.g-I-m
.t
auuiK|EH jVJP,KY|$̈5x"x_23>G2.11p+[ˉx(
P-$B)jXP@Woеpau1YaInMd}/|Sa:}..%Q:C@3 r6AtAyuh0gAƘn?%$'ab
8;d_&g@̻:;opʭy1&6!% ,G |ԁ[t-jh$#x#
q26!**2BQ:!3jGt['03h
َWYPiUt DzUnoئ^M_=
-~i@Ԋb=z4,Ehc8$Vhe4
bK
<-hwHP?9]C ]5C$ճU13$DL: t
b9Zr ghaYsxi2i
C)OXTߵٙIR߲Qiya*՛u"eY[$+7oELOTiO@k3دs4v^B6wH1@VQ ]Q,R;h܊Tr&0c%EޱxէZviZ&pn*)
g`,DSi4`nD`UE6m2ѪTc
yhP~@mE,68ȗ>CٌtMhQcRbIkÔ(3G!hZ)Yb@:8^l/t{\s@k^$7Z,V:Ҏ]Z}Clф#[ƈ@hC(=$^H7OQ^FJ0Bi}iѤk®=Ĩ'չVlt#X4Lg,_wHLLw_Wϴ_n< S.s|3;hAL9jFDJQ<3v〘E}%i:,0_uqbC_Aioi6&8m.MgG^P+6C;9%B)9T7hywwZb 14N!hl\UeiM40:ѡY椄IRCevSZሔ5R sRK23SFq-
endstream
endobj
64 0 obj
<<
/Length 1914
/Filter /FlateDecode
>>
stream
HW7+WHu
V>`V,]UݳvɺX^bٮa/9oioaٶu]ZVtv 6Aއ]}d
PZ5'!QR'ݓ2BE]Ղ1ȴDo\5Eh rQm#+T OXаqoEVupW7w$\tUY eqj)ܰ5OӇn>}}еd/ncqW{P]~辰MImme=_}ݞ|ۯǯg"(mYE=ĴVT-TucCg
V"ucіMKܹۡAܐE0/6`+ajOnK?.gRj콭Z!8jx*V煄qЩ 'OycX1c-8VL
;/a ?aG?v0